Interactions
Description ..........
Interactant
Other Gene
PDIP46 interacts with p50 subunit of DNA polymerase delta.NP_&&Q9BY77&&Q9BY77&&Q9BY77&&Q9BY77&Co-fractionationBioGRID:123998&Affinity Capture-MSBioGRID:123998&Co-fractionationBioGRID:123998&Affinity Capture-MSBioGRID:123998&Affinity Capture-W Biochemical A Two-hybridBioGRID:123998&Affinity Capture-MSBioGRID:123998&Affinity Capture-MSBioGRID:123998&Two-hybridBioGRID:123998&Affinity Capture-MSBioGRID:123998&Co-fractionationBioGRID:123998&Affinity Capture-MSBioGRID:123998&Affinity Capture-MSBioGRID:123998&Affinity Capture-MSBioGRID:123998&Affinity Capture-MSBioGRID:123998&
General gene information
MakersPhenotypes
GeneOntology
FunctionEvidenceIEAIEAIPIProcessEvidenceIMPIDAComponentEvidenceIDAIDATASIDAIDAIDAIDA
Alternate HuRef1.
NW_ Alternate HuRef 87792.
AC_ Alternate HuRef 940391,complement3.
AC_ Alternate HuRef 940391,complement4.
AC_ Alternate HuRef 940391,complement5.
NW_ Alternate HuRef 87796.
NW_ Alternate HuRef 87797.
NW_ Alternate HuRef 87798.
AC_ Alternate HuRef 940391,complementAlternate CHM1_1.11.
NC_ Alternate CHM1_1.1 938883,complement2.
NW_ Alternate CHM1_1.1 329249,complement3.
NC_ Alternate CHM1_1.1 938883,complement4.
NC_ Alternate CHM1_1.1 938883,complement5.
NW_ Alternate CHM1_1.1 329249,complement6.
NW_ Alternate CHM1_1.1 329249,complement7.
NW_ Alternate CHM1_1.1 329249,complement8.
NC_ Alternate CHM1_1.1 938883,complementReference GRCh37.p13 Primary Assembly1.
NC_ Reference GRCh37.p13 Primary Assembly 979726,complement2.
NT_ Reference GRCh37.p13 Primary Assembly 370295,complement3.
NC_ Reference GRCh37.p13 Primary Assembly 979726,complement4.
NT_ Reference GRCh37.p13 Primary Assembly 370295,complement5.
NC_ Reference GRCh37.p13 Primary Assembly 979726,complement6.
NT_ Reference GRCh37.p13 Primary Assembly 370295,complement7.
NC_ Reference GRCh37.p13 Primary Assembly 979726,complement8.
NT_ Reference GRCh37.p13 Primary Assembly 370295,complement
Related Sequences
NucleotideProteinGenomicNoneGenomicNoneGenomicNoneGenomicGenomicGenomicGenomicGenomicNoneGenomicmRNAmRNAmRNAmRNANonemRNAmRNANonemRNAmRNANonemRNANonemRNAmRNAmRNAmRNAmRNAmRNAmRNANonemRNAmRNAmRNAmRNAmRNAmRNAmRNAmRNAProtein AccessionLinksQ9BY77.2
Additional LinksCD7 CD7 molecule [Homo sapiens (human)] - Gene - NCBI
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CategoriesSequence contentStatusChromosome locationsFromToApply
FormatFull ReportFull Report (text)Gene TableGene Table (text)GeneRIFSummarySummary (text)TabularTabular (text)ASN.1XMLUI ListApplyChoose DestinationFileClipboardCollectionsFormatFull Report (text)Gene Table (text)Summary (text)Tabular (text)ASN.1XMLUI ListCreate FileAdd to ClipboardAdd to Collections
CD7provided by
CD7 moleculeprovided by
Primary source
See related
protein coding
RefSeq status
E M C C V E M E E P H C H Homo
Also known as
GP40; TP41; Tp40; LEU-9
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008]
See CD7 in
Annotation release
GRCh38.p2 ()
NC_ (317604, complement)
previous assembly
GRCh37.p13 ()
NC_ (275480, complement)
Chromosome 17 - NC_
Genomic Sequence:
NC_ Chromosome 17 Reference GRCh38.p2 Primary Assembly
NC_ Chromosome 17 Alternate CHM1_1.1
NC_ Chromosome 17 Reference GRCh37.p13 Primary Assembly
Go to nucleotide:
Related articles in PubMed
GeneRIFs: Gene References Into Functions
Title: CD7 promotes extramedullary involvement of the B-cell acute lymphoblastic leukemia line Tanoue by enhancing integrin β2-dependent cell adhesiveness.
Title: CADM1 expression and stepwise downregulation of CD7 are closely associated with clonal expansion of HTLV-I-infected cells in adult T-cell leukemia/lymphoma.
Title: SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.
Title: Autocrine GM-CSF transcription in the leukemic progenitor cell line KG1a is mediated by the transcription factor ETS1 and is negatively regulated through SECTM1 mediated ligation of CD7.
Title: CD7 in acute myeloid leukemia: correlation with loss of wild-type CEBPA, consequence of epigenetic regulation.
Title: Frequent CD7 antigen loss in aggressive natural killer-cell leukemia: a useful diagnostic marker.
Title: Twist2 regulates CD7 expression and galectin-1-induced apoptosis in mature T-cells.
Title: Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemia.
Title: Glycodelin A triggers T cell apoptosis through a novel calcium-independent galactose-binding lectin activity.
Title: Overexpression of CD7 in classical Hodgkin lymphoma-infiltrating T lymphocytes.
Protein interactions
Interaction
Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD7
Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD7
GDB:180952 (e-PCR)
RH103593 (e-PCR)
GDB:178581 (e-PCR)
G29875 (e-PCR)
Evidence Code
Traceable Author Statement
Inferred from Electronic Annotation
Traceable Author Statement
Non-traceable Author Statement
Evidence Code
Inferred from Direct Assay
Traceable Author Statement
Traceable Author Statement
Traceable Author Statement
Preferred Names
T-cell antigen CD7
T-cell antigen CD7
CD7 antigen (p41)
T-cell leukemia antigen
T-cell surface antigen Leu-9
p41 protein
These reference sequences exist independently of genome builds.
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in
mRNA and Protein(s)
T-cell antigen CD7 precursor
Status: REVIEWED
Source sequence(s)
Consensus CDS
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Conserved Domains (2)
Location:37 → 131
IgV; Immunoglobulin variable domain (IgV)
Location:36 → 131
IG_ Immunoglobulin like
The following sections contain reference sequences that belong to a
specific genome build.
Reference GRCh38.p2 Primary Assembly
NC_ Reference GRCh38.p2 Primary Assembly
mRNA and Protein(s)
Conserved Domains (2)
Location:1 → 31
IG_ Immunoglobulin like
Location:1 → 31
V- Immunoglobulin V-set domain
Alternate CHM1_1.1
NC_ Alternate CHM1_1.1
Protein Accession
GenPept Link
UniProtKB Link
The following
resources are supplied by external providers. These providers are responsible for maintaining the links.
Interologous Interaction Database
Pancreatic Expression Database
CREB Target Gene Database
Domain Mapping of Disease Mutations
FuncBase Gene Function Prediction Viewer
GeneNetwork
GoPubMed Proteins
HuRef Browser
Human eFP Browser
Ingenuity Pathways Analysis
Kyoto Encyclopedia of Genes and Genomes
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs
PhosphoSitePlus
Protein Ontology Consortium
The Gene Wiki
The Weizmann Institute of Science GeneCards and MalaCards databases
iHOP - Information Hyperlinked over Proteins
iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
Addgene Non-profit plasmid repository
ExactAntigen/Labome
GeneCopoeia Inc.
Kazusa DNA Research Institute
Life Technologies
LifeSpan BioSciences, Inc.
NITE Biological Resource Center
PlasmID Repository at Harvard Medical School
Sino Biological Inc.
antibodies-online
GeneWeaver
InterologFinder.org
Novus Biologicals
QIAGEN GeneGlobe
Supplemental Content
Order cDNA clone
Related PubChem BioAssays
BioAssays related to the gene by protein target or RNAi target
Summarized PubChem Data on the gene, showing the active data by default
PubChem BioAssays done on the Gene target
BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record
BioAssays that contain the gene as the target of a RNAi reagent
BioProjects related to a gene
BioSystems
Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
Related medical variations
Conserved Domain Database
Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
Link from Gene to dbVar
Link to related EST entry
Full text in PubMedCentral identified from shared sequence links
Overlapping genes and two nearest non-overlapping genes on either side
Genome records having the gene annotated on corresponding genomic reference sequence.
Related GEO
Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
Link to related Nucleotide entry
Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
Related Probe entry
Link to related protein entry
PubChem Compounds
PubChem Substances
Links between Gene and PubMed are the result of the following:
1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required.
2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
GeneRIF -- Gene Reference Into Function
Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well.
http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
Citations in PubMed identified from shared sequence and PMC links.
Link to Protein RefSeqs
Link to Nucleotide RefSeq RNAs
Related SNP records
SNPs linked from GeneView
Gene Genotype Report
Link to related taxonomy entry
Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
CD7 CD7 molecule [Homo sapiens]Gene ID:924
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External link. Please review our .FLNC filamin C, gamma [Homo sapiens (human)] - Gene - NCBI
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CategoriesSequence contentStatusChromosome locationsFromToApply
FormatFull ReportFull Report (text)Gene TableGene Table (text)GeneRIFSummarySummary (text)TabularTabular (text)ASN.1XMLUI ListApplyChoose DestinationFileClipboardCollectionsFormatFull Report (text)Gene Table (text)Summary (text)Tabular (text)ASN.1XMLUI ListCreate FileAdd to ClipboardAdd to Collections
FLNCprovided by
filamin C, gammaprovided by
Primary source
See related
protein coding
RefSeq status
E M C C V E M E E P H C H Homo
Also known as
ABPA; ABPL; FLN2; MFM5; MPD4; ABP-280; ABP280A
This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
See FLNC in
Annotation release
GRCh38.p2 ()
previous assembly
GRCh37.p13 ()
Chromosome 7 - NC_
Genomic Sequence:
NC_ Chromosome 7 Reference GRCh38.p2 Primary Assembly
NG_ RefSeqGene
NC_ Chromosome 7 Alternate CHM1_1.1
NC_ Chromosome 7 Reference GRCh37.p13 Primary Assembly
Go to nucleotide:
Related articles in PubMed
GeneRIFs: Gene References Into Functions
Title: A novel structural unit in the N-terminal region of filamins.
Title: Altered mucosal DNA methylation in parallel with highly active Helicobacter pylori-related gastritis.
Title: Cyclic AMP-Rap1A signaling mediates cell surface translocation of microvascular smooth muscle α2C-adrenoceptors through the actin-binding protein filamin-2.
Title: Impairment of protein degradation in myofibrillar myopathy caused by FLNC/filamin C mutations.
Title: Structural interaction and functional regulation of polycystin-2 by filamin.
Title: Distal myopathy with upper limb predominance caused by filamin C haploinsufficiency.
Title: Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy.
Title: A novel heterozygous deletion-insertion mutation ( del/GTTTGT ins) in exon 18 of the filamin C gene causes filaminopathy in a large Chinese family.
Title: Case-control genome-wide association study of attention-deficit/hyperactivity disorder.
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
GeneReviews: Not available
Protein interactions
Interaction
HIV-1 gp120 promotes filamin binding to both CD4 and CXCR4
A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin
RH99004 (e-PCR)
Inferred from Physical Interaction
Inferred from Physical Interaction
Inferred from Physical Interaction
Evidence Code
Traceable Author Statement
Inferred from Electronic Annotation
Evidence Code
Inferred from Electronic Annotation
Traceable Author Statement
Inferred from Direct Assay
Inferred from Electronic Annotation
Traceable Author Statement
Inferred from Direct Assay
Inferred from Direct Assay
Inferred from Direct Assay
Inferred from Electronic Annotation
Preferred Names
ABP-280-like protein
ABP-L, gamma filamin
actin binding protein 280
These reference sequences exist independently of genome builds.
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in
NG_ RefSeqGene
mRNA and Protein(s)
filamin-C isoform b
Status: REVIEWED
Description
Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
Source sequence(s)
Consensus CDS
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Conserved Domains (3)
Location:1443 → 1536
IG_FLMN; Filamin-type immunoglobulin domains
Location:37 → 141
CH; Calp actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Location:2374 → 2460
F Filamin/ABP280 repeat
filamin-C isoform a
Status: REVIEWED
Description
Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
Source sequence(s)
Consensus CDS
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Conserved Domains (3)
Location:1443 → 1536
IG_FLMN; Filamin-type immunoglobulin domains
Location:37 → 141
CH; Calp actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
Location:2407 → 2493
F Filamin/ABP280 repeat
The following sections contain reference sequences that belong to a
specific genome build.
Reference GRCh38.p2 Primary Assembly
NC_ Reference GRCh38.p2 Primary Assembly
Alternate CHM1_1.1
NC_ Alternate CHM1_1.1
Protein Accession
GenPept Link
UniProtKB Link
FLNC homepage - Leiden Muscular Dystrophy pages
The following
resources are supplied by external providers. These providers are responsible for maintaining the links.
Interologous Interaction Database
Breast Cancer TissueBank Bioinformatics Portal
Pancreatic Expression Database
CREB Target Gene Database
Domain Mapping of Disease Mutations
FuncBase Gene Function Prediction Viewer
GeneNetwork
GoPubMed Proteins
HuRef Browser
Human Gene Mutation Database
Human eFP Browser
Ingenuity Pathways Analysis
Kyoto Encyclopedia of Genes and Genomes
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs
PhosphoSitePlus
Protein Ontology Consortium
The Gene Wiki
The Weizmann Institute of Science GeneCards and MalaCards databases
Vertebrate Genome Annotation (VEGA) database
iHOP - Information Hyperlinked over Proteins
iRefWeb - iRefIndex release 9.0 - Consolidated Interactome
Addgene Non-profit plasmid repository
ExactAntigen/Labome
GeneCopoeia Inc.
Life Technologies
LifeSpan BioSciences, Inc.
NITE Biological Resource Center
antibodies-online
GeneWeaver
InterologFinder.org
QIAGEN GeneGlobe
Supplemental Content
3D structure of a gene
Related PubChem BioAssays
BioAssays related to the gene by protein target or RNAi target
Summarized PubChem Data on the gene, showing the active data by default
PubChem BioAssays done on the Gene target
BioAssays that contain the gene as the target of a RNAi reagent
BioProjects related to a gene
BioSystems
Links between Entrez Gene and
'Books' are established if a GeneID is explicitly referenced in a book.
Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
Related medical variations
Conserved Domain Database
Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
Link from Gene to dbVar
Link to related EST entry
Full text in PubMedCentral identified from shared sequence links
Overlapping genes and two nearest non-overlapping genes on either side
Genome records having the gene annotated on corresponding genomic reference sequence.
Related GEO
Tests for this gene in the NIH Genetic Testing Registry
Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
Related information in MedGen
Link to related Nucleotide entry
Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
Related Probe entry
Link to related protein entry
PubChem Compounds
PubChem Substances
Links between Gene and PubMed are the result of the following:
1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required.
2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
GeneRIF -- Gene Reference Into Function
Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well.
http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
Citations in PubMed identified from shared sequence and PMC links.
Link to Protein RefSeqs
Link to Nucleotide RefSeq RNAs
Link to Nucleotide RefSeqGenes
Related SNP records
SNPs linked from GeneView
Gene Genotype Report
Related Clinical SNP
Link to related taxonomy entry
Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
FLNC filamin C, gamma [Homo sapiens]Gene ID:2318
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