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+ 11.97Instituto Federal de Educa??o, Ciência e Tecnologia do CearáShow more authorsAs redes neurais artificiais geralmente s?o aplicadas na solu??o de problemas complexos. Em problemas mais desafiadores, ao aumentar o número de neur?nios normalmente é possível conseguir uma maior eficiência. Porém, esse aumento deve ser bem planejado, pois a partir de certa quantidade a eficiência tende a cair. Desta forma, este artigo apresenta uma análise da influencia na quantidade de neur?nios de uma rede neural, para o reconhecimento de caracteres de uma placa de carro. Os testes realizados utilizaram 49 fotos da parte frontal de carros. O resultado obtido mostra que 30 neur?nios s?o ideais para o reconhecimento dos caracteres da placa, obtendo uma taxa de acerto de 97.5%Discover the world's research15+ million members118+ million publications700k+ research projects
This research doesn't cite any other publications.ProjectConference PaperDecember 2016RESUMO: A leitura de informa??es contidas em papeis ainda é uma tarefa bastante importante e apresenta uma grande aplica??o nos setores comerciais. Fazer a documenta??o destas informa??es e transferir para o computador requer bastante tempo e muitas vezes pode gerar erros. O Reconhecimento ?ptico de Caracteres, mesmo que seja algo estudado há bastante tempo, ainda está em constante estudo. O... [Show full abstract]ThesisJune 2014O mercado de dispositivos móveis continua em crescente ascens?o e com ele diversos apli- cativos inovadores est?o sendo criados. Muitas vezes é utilizada Inteligência Artificial (IA) em aplica??es que visam mais intera??o dos usuários com o dispositivo. Uma aplica??o comum de IA é no reconhecimento dos caracteres fornecidos pelo usuário através da escrita manual. Neste sentido, o presente... [Show full abstract]ThesisDecember 2009RESUMO: O processamento e a análise de imagens digitais s?o campos que vêm crescendo continuamente e ocupando importantes espa?os nos mais diversos meios, quais sejam: análise de imagens médicas, análise de microfotogra as de gr?os, análise de imagens de satélites, dentre outras. Há alguns anos, os métodos de detec??o, identi- ca??o e análise de bordas vêm sendo um importante recurso no... [Show full abstract]ThesisAugust 2012O auxílio ao diagnóstico através da visualiza??o de imagens médicas vêm sendo utilizado em diversas áreas da Medicina tais como pneumologia, cardiologia, traumatologia, neurologia, dentre outras. Na área da cardiologia, várias aplica??es clínicas têm sido propostas para a análise de doen?as cardíacas através da quantifica??o e avalia??o da dessincronia ventricular esquerda durante a deforma??o... [Show full abstract]Conference PaperOctober 2010A simula??o e modelagem de sistemas s?o técnicas constantemente melhoradas através da Computa??o. Uma das melhorias proporcionadas pelo avan?o da computa??o é o avan?o das técnicas de modelagem e a triangula??o é uma delas. A gera??o de malhas triangulares tem aplica??es em temas como a modelagem de personagens de jogos para a Computa??o Gráfica, demarca??o de espa?o na Topografia/Cartografia,... [Show full abstract]Last Updated: 18 Mar 18Aberrant 5-Hydroxymethylcytosine Levels Correlate With Poor Overall Survival In Acute Myeloid Leukemia | Blood Journal
Aberrant 5-Hydroxymethylcytosine Levels Correlate With Poor Overall Survival In Acute Myeloid Leukemia
Leonie I Kroeze, Mariam G Aslanyan, Arno van Rooij, Theresia N Koorenhof-Scheele, Marion Massop, Thomas Carell, Jan B Boezeman, Jean-Pierre Marie, Constantijn J.M. Halkes, Theo M. de Witte, Gerwin Huls, Stefan Suciu, Ron Wevers, Bert A. van der Reijden and Joop H. Jansen
Blood 122:1261;
Leonie I KroezeDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands, Mariam G AslanyanDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands, Arno van RooijDepartment of Laboratory Medicine, Laboratory for Genetic, Endocrine and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, Theresia N Koorenhof-ScheeleDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands, Marion MassopDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands, Thomas CarellDepartment of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Ludwig-Maximilians-University, Munich, Germany, Jan B BoezemanDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands, Jean-Pierre MarieDepartment Hematology and Tumor Bank, Saint-Antoine Hospital, AP-HP & University Pierre & Marie Curie, Paris, France, Constantijn J.M. HalkesDepartment of Hematology, Leiden University Medical Center, Leiden, Netherlands, Theo M. de WitteDepartment of Tumor Immunology, Chairman of MDS subcomittee of CMWP, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands, Gerwin HulsDepartment of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, Stefan SuciuEORTC Headquarters, EORTC Leukemia Group, Brussels, Belgium, Ron WeversDepartment of Laboratory Medicine, Laboratory for Genetic, Endocrine and Metabolic Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, Bert A. van der ReijdenDepartment of Laboratory Medicine, Laboratory of Hematology, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, Nijmegen, Netherlands, Joop H. JansenLaboratory of Hematology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
AbstractBackground Patients with acute myeloid leukemia (AML) frequently harbor mutations in genes involved in the DNA (hydroxy)methylation pathway (DNMT3A, TET2, IDH1, and IDH2). In addition, changes in DNA methylation have been implicated in the pathogenesis of AML. Recently it was discovered that TET proteins are able to convert 5-methylcytosine into 5-hydroxymethylcytosine (5hmC), which is an important intermediate in the demethylation pathway. In this study, we measured 5-hydroxymethylcytosine levels in AML patients, and correlated these with mutational status and overall survival (OS).Patients and methods Samples from 206 clinically and molecularly well-characterized younger adult AML patients (≤60 years), included in the EORTC/GIMEMA AML-12 06991 clinical trial, were analyzed for mutations in DNMT3A, TET2, IDH1 and IDH2. 5-hydroxymethylcytosine levels were measured using HPLC-MS/MS.Results In healthy control cells, 5hmC levels were confined to a narrow range (1.5 fold difference), whereas in AML cells, a much wider range was detected (15 fold difference). In remission, 5hmC values were normalized to levels comparable to healthy bone marrow and peripheral blood, indicating that the aberrant 5hmC levels at diagnosis are intrinsic to the leukemic cells. Patients with mutations in TET2 and patients with mutations in IDH1/2 had significantly lower levels of 5hmC compared to patients without mutated TET2 and IDH1/2 (both P&.001), whereas mutations in DNMT3A did not influence 5hmC levels. Patients with bi-allelic TET2 inactivation displayed lower 5hmC levels than patients with one affected allele (P=.003). Among the patients that did not harbor TET2 or IDH mutations, still a wide variation in 5hmC levels was observed, and importantly, both low and very high 5hmC levels correlated with inferior OS (P=.02, HR=1.80 and P=.04, HR=1.97, respectively). Multivariate analysis revealed that abnormal levels of 5hmC were independent prognostic indicators for OS. The difference in OS could not be explained by an initial inferior response to therapy, however, the relapse rate was considerably higher in patients with low and very high 5hmC levels compared to patients with intermediate 5hmC.Conclusion Both low and very high levels of 5hmC are markers of poor prognosis in AML, lending further support for testing therapies targeting the DNA hydroxymethylation pathway.Disclosures: No relevant conflicts of interest to declare.* Asterisk with author names denotes non-ASH members.
Volume: 122
Pages: 1261
DOI: https://doi.org/
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Mariam G Aslanyan, Arno van Rooij, Theresia N Koorenhof-Scheele, Marion Massop, Thomas Carell, Jan B Boezeman, Jean-Pierre Marie, Constantijn J.M. Halkes, Theo M. de Witte, Gerwin Huls, Stefan Suciu, Ron Wevers, Bert A. van der Reijden, Joop H. Jansen
Blood 122 (21) 1261;
Citation Manager Formats
, ., Aslanyan, M. G., van Rooij, A., Koorenhof-Scheele, T. N., Massop, M., Carell, T., Boezeman, J. B., Marie, J., Halkes, C. J., de Witte, T. M., Huls, G., Suciu, S., Wevers, R., & van der Reijden, B. A.
Aberrant 5-Hydroxymethylcytosine Levels Correlate With Poor Overall Survival In Acute Myeloid Leukemia.
Accessed August 11, 2018.
Retrieved from http://www.bloodjournal.org/content/122/21/1261.
Mariam G Aslanyan, Arno van Rooij, Theresia N Koorenhof-Scheele, Marion Massop, Thomas Carell, Jan B Boezeman, Jean-Pierre Marie, Constantijn J.M. Halkes, Theo M. de Witte, Gerwin Huls, Stefan Suciu, Ron Wevers, Bert A. van der Reijden, Joop H. Jansen
Blood 122 (21) 1261;
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