hello. i’mflex bisonn

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István ?brahám
Allan Herbison
[01 Jan ):945-951]
Comparative Study, Research Support, Non-U.S. Gov't, Journal Article
Rapid effects of estrogen have now been identified throughout the brain but the extent to which these actions may be different in males and females is unknown. Previous work has shown that estrogen rapidly phosphorylates Ser133 of cAMP responsive element binding protein (CREB) through a non-genomic mechanism. Using this indicator, we have examined here whether non-genomic estrogen actions occur in a sexually dimorphic manner within the adult brain. Male and female mice were gonadectomized and 3 weeks later treated with 17-beta-estradiol or vehicle for 1 h prior to perfusion fixation and subsequent CREB and phosphorylated CREB (pCREB) immunostaining of brain sections. The numbers of cells expressing CREB immunoreactivity were not altered by estrogen treatment or different in males and females in any of the brain regions examined. However, estrogen treatment significantly (P&0.05) increased pCREB-immunoreactive cell numbers in the medial preoptic area, ventrolateral division of the ventromedial nucleus, medial septum and CA1 region of the hippocampus of female mice. In contrast, estrogen increased pCREB levels in the medial septum and CA1 but not in the preoptic area or ventromedial nucleus of male mice. To evaluate the extent to which non-genomic estrogen actions may be sexually differentiated within a single neuronal phenotype, dual labeling immunocytochemistry was undertaken to evaluate the gonadotropin-releasing hormone (GnRH) neuronal phenotype. Estrogen significantly (P&0.05) increased the numbers of GnRH neurons expressing pCREB in female but not male mice. Together, these results demonstrate the existence of a marked sex difference in estrogen's non-genomic effects upon brain function in vivo.
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Better When I’m Dancin’的
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Better When I’m Dancin’的歌词
Don't think about it
Just move your body
Listen to the music
Sing, oh, ey, oh
Just move those left feet
Go ahead, get crazy
Anyone can do it
Sing, oh, ey, oh
Show the world you've got that fire
Feel the rhythm getting louder
Show the room what you can do
Prove to them you've got the moves
I don't know about you
But I feel better when I'm dancing, yeah, yeah
Better when I'm dancing, yeah, yeah
We can do this together
I bet you feel better when you're dancing, yeah, yeah
When you finally let go
And you slay that solo
Cause you listen to the music
Sing, oh, ey, oh
Cause you're confident, babe
And you make your hips sway
We knew that you could do it
Sing, oh, ey, oh
Show the world you've got that fire
Feel the rhythm getting louder
Show the room what you can do
Prove to them you've got the moves
I don't know about you
But I feel better when I'm dancing, yeah, yeah
Better when I'm dancing, yeah, yeah
We can do this together
I bet you feel better when you're dancing, yeah, yeah
Oh, ey, oh
Oh, ey, oh
I feel better when I'm dancing
I'm better when I'm dancing
Oh, ey, oh
Oh, ey, oh
I feel better when I'm dancing, yeah, yeah
Better when I'm dancing, yeah, yeah
Don't you know we can do this together
Bet you feel better when you're dancing, yeah, yeah
You got to move it
I feel better when I'm dancing
Better when I'm dancing
Feel better when I'm, yeah, yeah
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